"Synthesis and Characterization of Novel Imidazo (1, 2-a) pyrimidine Derivatives and their Evaluation for Antiepileptic and Analgesic activity"

Affordable and practical synthesis methods in drug development have always been very attractive. Herein, microwave assisted synthesis was utilized to prepare Imidazo[1,2-a] pyrimidine derivatives were obtained by the reaction between 2-aminopyrimidine, aldehyde, and benzyl isocyanide. It gives 82-92 % yields. As well as demonstrating the Anti-MES efficacy of compound 2, its potency against seizures induced by pentylenetetrazole, were also established, with the results suggesting that GABA-mediated mechanisms might be involved in its anticonvulsant activity, such as enhancing of GABAergic neurotransmission or activity, activate GAD or inhibit GABA-T, and GABAA-mediated mechanisms. For the analgesic activities, hotplate method were employed. Derivative-II was found to have the significant activity by hot-plate method.