Sangeeta T. Sankpal & Krishna S. Pathade
Appasaheb Birnale College of Pharmacy, Sangli, India-416416
Akshay R. Yadav
Rajarambapu College of Pharmacy, Kasegaon, India-415404
Abstract
Affordable and practical synthesis methods in drug development have always been very
attractive. Herein, microwave assisted synthesis was utilized to prepare Imidazo[1,2-a]
pyrimidine derivatives were obtained by the reaction between 2-aminopyrimidine, aldehyde, and
benzyl isocyanide. It gives 82-92 % yields. As well as demonstrating the Anti-MES efficacy of
compound 2, its potency against seizures induced by pentylenetetrazole, were also established,
with the results suggesting that GABA-mediated mechanisms might be involved in its
anticonvulsant activity, such as enhancing of GABAergic neurotransmission or activity, activate
GAD or inhibit GABA-T, and GABAA-mediated mechanisms. For the analgesic activities, hotplate method were employed. Derivative-II was found to have the significant activity by hot-plate
method.