"Synthesis and Biological Evaluation of Some Novel Thiophenes"


Gunjan Kumari & Naresh Kumar
B. N. Mandal University, Madhepura – 852113, Bihar, India.


A series of tetrahydrobenzothiophene was synthesized with an objective to develop novel and potent antimicrobial agent of synthetic origin. First, N-propylamine and Ethyl cyanoacetate were reacted to yield Propyl cyanoacetamide I. Then, compound (I) was reacted with cyclohexanone to obtain an intermediate, which was processed to 2-amino-3-N- (propylcarboxamido)- 4, 5, 6, 7- tetra hydrobenzo (b) thiophene (II) by well known and versatile Gewald reaction. Reaction of compound II with different aromatic aldehyde yielded the title compound II a-k. The synthesized compound were purified, characterized and evaluated for antimicrobial activity. Most of the compound exhibited moderate to significant activities.