"Haematological and biochemical changes after exposure to Phoebe wightii Meisn methanol extract in rats."

Acute and subchronic toxicities of the methanolic extract from the Phoebe wightiiwere studied in male rats. Oral administration of the extract at a single dose of 250 and 500 mg/kg body weight did not produce signs of toxicity, behavioral changes, mortality or differences on gross appearance of internal organs. The subchronic toxicity was determined by oral feeding the test substance at the doses of 250 and 500 mg/kg body weight for 28days. The examinations of signs, animal behavior and health monitoring showed no signs of abnormalities in the test groups as compared to the controls. The test and control groups were analyzed by measuring their final body and organ weights, taking necropsy, and examining hematological parameters, blood clinical chemistry and histopathology features. The results suggest that Phoebe wightiiadministered orally did not cause acute or sub chronic toxicities to male rats.