"EFFECT OF HIGH INTENSITY AEROBIC RUN ON SYSTEMIC BIOAVAILABILITY OF SELECTED MYOKINESAMONG ELITE MIDDLE DISTANCE RUNNERS IN INDIA"

Authors

Arun Kumar Chatla & V. Satyanarayana (Professor)
Osmania University, Telangana, India.

Abstract

Exercise induced myokines secreted by the active muscle tissue during high intensityacute aerobic exercise executes autocrine, paracrine and endocrine cell signalling, intra and inter cellular coordination for homeo-dynamiceffect. For the studyselected myokinesi.e., IL-6, IL-8, IL-15, serum BDNF, Irisin &hormone EPO were investigated through the impact of acute aerobic run.A total of fifteenelite male athletes (n=15)aged21 ± 2.3 years were recruited.The serum samples were collected from ante-medial cubital vein before and immediately after the athletic event, the quantitative assessment of the selected serum myokines and EPO wasdone usingsandwich Enzyme Linked Immunosorbent Assay(ELISA).The resultswere statistically analysed Mean ± Standard Deviation with paired t-test at α=0.05 significance.The serum IL-6, IL-8, IL-15, BDNF and Irisin shown significant increasewhere in the p values are <0.01 {IL-6 (before 0.79±0.51 pgm/ml after 5.70±1.59 pgm/ml), IL-8 (before 28.39±10.36 pgm/ml after 61.33±13.63pgm/ml), IL-15 (before 4.58±2.98 pgm/ml after , 8.53± 3.91pgm/ml), serum BDNF (before 14.82±5.86 ngm/ml after 39.01±10.69 nmg/ml)& Irisin (before 89.78±23.82 ngm/ml after 158.88±43.84 ngm/ml)} but serum Erythropoietin levels remained hence the p-value is 0.566(before13.398±4.656 µ IU/ml and after 13.631±5.74 µ IU/ml). The high intensity acute aerobic exercise showed distinct impact on the selected myokines content in the serum levels of the trained elite athletes before and after event but remained the same with EPO.